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CAS No.: 126-07-8

灰黄霉素 Catalog No. CSN11119

Synonyms: (+)-Griseofulvin;Grifulvin V;Gris-PEG

(+)-Griseofulvin is a naturally occuring centrosomal clustering inhibitor and induces keratin cytoskeleton alterations. It is also an antifungal drug.

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生物活性

实验方案

技术信息

生物活性

描述(+)-Griseofulvin (Griseofulvin) is a metabolic product of Penicillium spp. It was the first available oral agent for the treatment of dermatophytoses and has now been used for more than forty years. (+)-Griseofulvin can inhibit the fungal cell mitosis and nuclear acid synthesis, probable interfere with the function of microtubules. Griseofulvin has also anti-inflammatory properties and some direct vasodilatory effects when it is used in high doses^[3]. Griseofulvin is an orally administered antifungal drug that affects microtubule formation in vitro and interferes with microtubule dynamics in vivo. Griseofulvin affected porcine oocyte in vitro maturation and following embryo development by disturbing microtubule dynamics^[4]. The antifungal drug griseofulvin inhibits mitosis strongly in fungal cells and weakly in mammalian cells by affecting mitotic spindle microtubule (MT) function. Griseofulvin also blocks cell-cycle progression at G(2)/M and induces apoptosis in human tumor cell lines. Griseofulvin inhibited cell-cycle progression at prometaphase/anaphase of mitosis in parallel with its ability to inhibit cell proliferation. At its mitotic IC(50) of 20 muM, spindles in blocked cells displayed nearly normal quantities of MTs and MT organization similar to spindles blocked by more powerful MT-targeted drugs^[5]. Griseofulvin strongly suppressed the dynamic instability of individual microtubules in live MCF-7 cells by reducing the rate and extent of the growing and shortening phases. At or near half-maximal proliferation inhibitory concentration, griseofulvin dampened the dynamicity of microtubules in MCF-7 cells without significantly disrupting the microtubule network. Griseofulvin-induced mitotic arrest was associated with several mitotic abnormalities like misaligned chromosomes, multipolar spindles, misegregated chromosomes resulting in cells containing fragmented nuclei^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8347 mL
- 14.1737 mL
- 28.3474 mL
- 5 mM
- 0.5669 mL
- 2.8347 mL
- 5.6695 mL
- 10 mM
- 0.2835 mL
- 1.4174 mL
- 2.8347 mL

技术信息

CAS号

126-07-8

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H17ClO6

运输

蓝冰

分子量

352.77

别名

(+)-Griseofulvin;Grifulvin V;Gris-PEG;Fulvicin;Grisactin;Amudane;灰黄霉素

溶解度

DMSO	49.0 mg/mL (138.9 mM)
Water	Insoluble
Ethanol	Insoluble

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